Improvement of DHRA-DMDC Physical Access Software DBIDS Using Cloud Computing Technology: a Case Study

The U.S government has created and been executing an Identity and Management (IdM) vision to support a global, robust, trusted and interoperable identity management capability that provides the ability to correctly identify individuals and non-person entities in support of DoD mission operations. Many Directives and Instructions have been issued to standardize the process to design, re-designed new and old systems with latest available technologies to meet the visions requirements. In this thesis we introduce a cloud-based architecture for the Defense Biometric Identification System (DBIDS), along with a set of DBIDS Cloud Services that supports the proposed architecture. This cloud-based architecture will move DBIDS in the right direction to meet Dod IdM visions and goals by decoupling current DBIDS functions into DBIDS core services to create interoperability and flexibility to expand future DBIDS with new requirements. The thesis will show its readers how DBIDS Cloud Services will help Defense Manpower Data Center (DMDC) easily expanding DBIDS functionalities such as connecting to other DMDC services or federated services for vetting purposes. This thesis will also serve as a recommendation of a blue-print for DBIDS architecture to support new generation of DBIDS application. This is a step closer in moving DMDC Identity Enterprise Solution toward DoD IdM realizing vision and goals. The thesis also includes a discussion of how to utilize virtualized DBIDS workstations to address software-deployment and maintenance issues to resolve configuration and deployment issues which have been costly problems for DMDC over the years.http://archive.org/details/improvementofdhr109457379Civilian, Department of Defens

The transcriptional architecture of early human hematopoiesis identifies multilevel control of lymphoid commitment.

Understanding how differentiation programs originate from the gene-expression 'landscape' of hematopoietic stem cells (HSCs) is crucial for the development of new clinical therapies. We mapped the transcriptional dynamics underlying the first steps of commitment by tracking transcriptome changes in human HSCs and eight early progenitor populations. We found that transcriptional programs were extensively shared, extended across lineage-potential boundaries and were not strictly lineage affiliated. Elements of stem, lymphoid and myeloid programs were retained in multilymphoid progenitors (MLPs), which reflected a hybrid transcriptional state. By functional single cell analysis, we found that the transcription factors Bcl-11A, Sox4 and TEAD1 (TEF1) governed transcriptional networks in MLPs, which led to B cell specification. Overall, we found that integrated transcriptome approaches can be used to identify previously unknown regulators of multipotency and show additional complexity in lymphoid commitment

Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking

The potential of the diverse chemistries present in natural products (NP) for biotechnology and medicine remains untapped because NP databases are not searchable with raw data and the NP community has no way to share data other than in published papers. Although mass spectrometry techniques are well-suited to high-throughput characterization of natural products, there is a pressing need for an infrastructure to enable sharing and curation of data. We present Global Natural Products Social molecular networking (GNPS, http://gnps.ucsd.edu), an open-access knowledge base for community wide organization and sharing of raw, processed or identified tandem mass (MS/MS) spectrometry data. In GNPS crowdsourced curation of freely available community-wide reference MS libraries will underpin improved annotations. Data-driven social-networking should facilitate identification of spectra and foster collaborations. We also introduce the concept of ‘living data’ through continuous reanalysis of deposited data

Characterizations of Nonsmooth Robustly Quasiconvex Functions

© 2018, Springer Science+Business Media, LLC, part of Springer Nature. Two criteria for the robust quasiconvexity of lower semicontinuous functions are established in terms of Fréchet subdifferentials in Asplund spaces. The first criterion extends to such spaces a result established by Barron et al. (Discrete Contin Dyn Syst Ser B 17:1693–1706, 2012). The second criterion is totally new even if it is applied to lower semicontinuous functions on finite-dimensional spaces

Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking

The potential of the diverse chemistries present in natural products (NP) for biotechnology and medicine remains untapped because NP databases are not searchable with raw data and the NP community has no way to share data other than in published papers. Although mass spectrometry (MS) techniques are well-suited to high-throughput characterization of NP, there is a pressing need for an infrastructure to enable sharing and curation of data. We present Global Natural Products Social Molecular Networking (GNPS; http://gnps.ucsd.edu), an open-access knowledge base for community-wide organization and sharing of raw, processed or identified tandem mass (MS/MS) spectrometry data. In GNPS, crowdsourced curation of freely available community-wide reference MS libraries will underpin improved annotations. Data-driven social-networking should facilitate identification of spectra and foster collaborations. We also introduce the concept of 'living data' through continuous reanalysis of deposited data